Protein stability induced by ligand binding correlates with changes in protein flexibility
نویسندگان
چکیده
منابع مشابه
Protein Flexibility (4): Applications of NMA to Protein-Protein and Ligand-Protein Binding
The “lock-and-key” model emphasizes the importance of shape complementarity between two rigid structures. It can not be used to explain the conformation changes before and after binding. The “induced fit” model considers the conformation change due to non-rigid protein interactions. A geometric fit is ensured only after the structure rearrangement of the base protein. In the preexisting equilib...
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ژورنال
عنوان ژورنال: Protein Science
سال: 2003
ISSN: 0961-8368,1469-896X
DOI: 10.1110/ps.0240003